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Chromatography plays a crucial role in the chemical and pharmaceutical industries. New drug innovation, pilot studies, and process development are a few examples of how it's used. Preparative chromatography is a method used to separate and purify target compounds derived from complex mixtures so that they can be used in other applications. When conducting these separations, there are certain dependencies that must be considered as scientists develop their methods. In this video, you'll learn more about these interdependent relationships involved in chromatographic separations.
Fraction collection can be conducted in a variety of manners. Most commonly, however, fractions are collected either based on a simple function of time or more complex parameters set off by the signals from your detectors. Learn more in our helpful video, which highlights 8 common questions about fraction collection.
Preparative high performance chromatography (prep HPLC or LC) plays a crucial role in many industries. It is used to isolate and purify desired compounds, removing impurities and contaminants that can affect the quality and performance of the end product. In this video, we answer your questions about prep HPLC and how it can fit into your lab's purification workflows.
Peptides, or short chains of amino acids linked together by covalent bonds, are a growing class of pharmaceutical drugs. With a multitude of purification methods available for peptide purification, it’s possible to use several techniques together to enhance the purity of the peptide. This article covers the range of purification and detection methods used to purify peptides from process-related impurities and product-related impurities.
Pharmaceutical peptides can be generated in a variety of ways. They can be generated by breaking down proteins to release peptides or they can be synthesized chemically, one amino acid at a time. This article covers synthetic peptide purification, focusing on purification by liquid chromatography-mass spectrometry (LC-MS).
