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A natural product is described as a compound or substance produced by a living organism found in nature. For thousands of years, many cultures around the world have depended on traditional medicines found in nature. Over the last hundred years, many new FDA approved drugs have their origins in natural products and many of these are also used in commercial products including cosmetic and beauty products and dietary supplements.
Natural products can be both chemically synthesized or isolated from natural sources such as plant and tissue extracts, fermentation broths, etc. Active agents from natural sources are typically found in very low levels and must be extracted and purified to higher concentrations to demonstrate their specific activity. Gilson has a range of extraction and purification products to benefit your natural products workflows and more information can be found in our natural product-focused application notes.
Preparative high performance liquid chromatography (HPLC) is a well-established method for purifying target compounds. Method development is usually done at a smaller scale to define sufficient resolution between the peaks without wasting large amounts of sample. It is common to scale-up the purification from a smaller column to a larger preparative one - learn more in this technical note.
This high throughput HPLC purification system provides endless configurations for semi-preparative and preparative automated purification, supporting CROs, Pharma, and Biotech Research and Development groups in synthetic drug discovery. All configurations accommodate advanced injection and fraction collection capabilities within a single platform, with multiple detection options, including targeted mass (MS).
This ASPEC® system for positive pressure solid phase extraction (SPE) maximizes throughput by processing up to four samples in parallel. With its small footprint and multiple probes, it is the ideal choice for high-throughput SPE automation on 1, 3, or 6 mL cartridges. Combined with ASPEC SPE Cartridges, it generates reproducible and efficient sample cleanup for clinical, forensic, doping, food, and environmental testing labs.
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